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GLP-1 receptor agonists exert neuroprotective effects primarily by inhibiting microglial activation, the primary effector cells of neuroinflammation, thus reducing the production of proinflammatory cytokines (e.g., TNF- α , IL-1β) and alleviating inflammatory damage to brain parenchyma
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In the LOOK-AHEAD study, 5145 participants aged 45–76 years (mean BMI 36 kg/m 2 ) with T2D were randomized to either calorie restriction or diabetes support and education intervention (controls) [33]
